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Dual inhibitory action of trazodone on dorsal raphe serotonergic neurons through 5-HT(1A) receptor partial agonism and α(1)-adrenoceptor antagonism
Trazodone is an antidepressant drug with considerable affinity for 5-HT(1A) receptors and α(1)-adrenoceptors for which the drug is competitive agonist and antagonist, respectively. In this study, we used cell-attached or whole-cell patch-clamp recordings to characterize the effects of trazodone at s...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763016/ https://www.ncbi.nlm.nih.gov/pubmed/31557210 http://dx.doi.org/10.1371/journal.pone.0222855 |