Type I IFN protects cancer cells from CD8(+) T cell–mediated cytotoxicity after radiation

Treatment of tumors with ionizing radiation stimulates an antitumor immune response partly dependent on induction of IFNs. These IFNs directly enhance dendritic cell and CD8(+) T cell activity. Here we show that resistance to an effective antitumor immune response is also a result of IFN signaling i...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Jianzhou, Cao, Yunhong, Markelc, Bostjan, Kaeppler, Jakob, Vermeer, Jenny A.F., Muschel, Ruth J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763250/
https://www.ncbi.nlm.nih.gov/pubmed/31483286
http://dx.doi.org/10.1172/JCI127458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763250/
https://www.ncbi.nlm.nih.gov/pubmed/31483286
http://dx.doi.org/10.1172/JCI127458

Ejemplares similares