Viral miRNA adaptor differentially recruits miRNAs to target mRNAs through alternative base-pairing

HSUR2 is a viral non-coding RNA (ncRNA) that functions as a microRNA (miRNA) adaptor. HSUR2 inhibits apoptosis in infected cells by recruiting host miRNAs miR-142–3p and miR-16 to mRNAs encoding apoptotic factors. HSUR2’s target recognition mechanism is not understood. It is also unknown why HSUR2 u...

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Detalles Bibliográficos
Autores principales: Gorbea, Carlos, Mosbruger, Tim, Nix, David A, Cazalla, Demián
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763288/
https://www.ncbi.nlm.nih.gov/pubmed/31538617
http://dx.doi.org/10.7554/eLife.50530

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763288/
https://www.ncbi.nlm.nih.gov/pubmed/31538617
http://dx.doi.org/10.7554/eLife.50530

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