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Genome mining- and synthetic biology-enabled production of hypermodified peptides
The polytheonamides are among the most complex and biosynthetically distinctive natural products known to date. These potent peptide cytotoxins are derived from a ribosomal precursor processed by 49 mostly non-canonical posttranslational modifications. Since the producer is a "microbial dark ma...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763334/ https://www.ncbi.nlm.nih.gov/pubmed/31501509 http://dx.doi.org/10.1038/s41557-019-0323-9 |