In vivo genome editing using the Cpf1 ortholog derived from Eubacterium eligens

Cpf1 is an RNA-guided endonuclease that can be programmed to cleave DNA targets. Specific features, such as containing a short crRNA, creating a staggered cleavage pattern and having a low off-target rate, render Cpf1 a promising gene-editing tool. Here, we present a new Cpf1 ortholog, EeCpf1, as a...

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Detalles Bibliográficos
Autores principales: Ahn, Woo-Chan, Park, Kwang-Hyun, Bak, In Seon, Song, Hyung-Nam, An, Yan, Lee, Su-Jin, Jung, Mira, Yoo, Kyeong-Won, Yu, Dae-Yeul, Kim, Yong-Sam, Oh, Byung-Ha, Woo, Eui-Jeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763456/
https://www.ncbi.nlm.nih.gov/pubmed/31558757
http://dx.doi.org/10.1038/s41598-019-50423-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763456/
https://www.ncbi.nlm.nih.gov/pubmed/31558757
http://dx.doi.org/10.1038/s41598-019-50423-6

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