Targeting a moonlighting function of aldolase induces apoptosis in cancer cells

Muscle fructose-1,6-bisphosphate aldolase (ALDOA) is among the most abundant glycolytic enzymes in all cancer cells. Here, we show that the enzyme plays a previously unknown and critical role in a cancer cell survival. Simultaneous inhibition of ALDOA activity and interaction with F-actin cytoskelet...

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Detalles Bibliográficos
Autores principales: Gizak, Agnieszka, Wiśniewski, Janusz, Heron, Paul, Mamczur, Piotr, Sygusch, Jurgen, Rakus, Dariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763475/
https://www.ncbi.nlm.nih.gov/pubmed/31558701
http://dx.doi.org/10.1038/s41419-019-1968-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763475/
https://www.ncbi.nlm.nih.gov/pubmed/31558701
http://dx.doi.org/10.1038/s41419-019-1968-4

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