Insights Into the Resistance Mechanisms of Inhibitors to FLT3 F691L Mutation via an Integrated Computational Approach

Research has shown that FMS-like tyrosine kinase 3 (FLT3) may be a vital drug target for acute myeloid leukemia (AML). However, even though the clinically relevant F691L gatekeeper mutation conferred resistance to current FLT3 drug quizartinib, PLX3397 remained unaffected. In this study, the protein...

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Detalles Bibliográficos
Autores principales: Sun, Yunfeng, Xia, Zhongni, Zhao, Qinqin, Zheng, Bei, Zhang, Meiling, Ying, Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763581/
https://www.ncbi.nlm.nih.gov/pubmed/31619996
http://dx.doi.org/10.3389/fphar.2019.01050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763581/
https://www.ncbi.nlm.nih.gov/pubmed/31619996
http://dx.doi.org/10.3389/fphar.2019.01050

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