JNK Signaling Pathway Mediates Acetaminophen-Induced Hepatotoxicity Accompanied by Changes of Glutathione S-Transferase A1 Content and Expression

Acetaminophen (APAP) is an analgesic–antipyretic drug and widely used in clinics. Its overdose may cause serious liver damage. Here, we examined the mechanistic role of c-Jun N-terminal kinase (JNK) signaling pathway in liver injury induced by different doses of APAP. Male mice were treated with APA...

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Detalles Bibliográficos
Autores principales: Shi, Chenxi, Hao, Beili, Yang, Yang, Muhammad, Ishfaq, Zhang, Yuanyuan, Chang, Yicong, Li, Ying, Li, Changwen, Li, Rui, Liu, Fangping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763582/
https://www.ncbi.nlm.nih.gov/pubmed/31620005
http://dx.doi.org/10.3389/fphar.2019.01092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763582/
https://www.ncbi.nlm.nih.gov/pubmed/31620005
http://dx.doi.org/10.3389/fphar.2019.01092

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