At Least Two Genes Encode Many Variants of Irak3 in Rainbow Trout, but Neither the Full-Length Factor Nor Its Variants Interfere Directly With the TLR-Mediated Stimulation of Inflammation

The interleukin-1-receptor-associated kinase 3 (IRAK3) is known in mammals as a negative feedback regulator of NF-κB-mediated innate-immune mechanisms. Our RNA-seq experiments revealed a prototypic 1920-nt sequence encoding irak3 from rainbow trout (Oncorhynchus mykiss), as well as 20 variants that...

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Detalles Bibliográficos
Autores principales: Rebl, Alexander, Rebl, Henrike, Verleih, Marieke, Haupt, Stephanie, Köbis, Judith M., Goldammer, Tom, Seyfert, Hans-Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763605/
https://www.ncbi.nlm.nih.gov/pubmed/31616422
http://dx.doi.org/10.3389/fimmu.2019.02246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763605/
https://www.ncbi.nlm.nih.gov/pubmed/31616422
http://dx.doi.org/10.3389/fimmu.2019.02246

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