Cargando…

Phospho-Protein Arrays as Effective Tools for Screening Possible Targets for Kinase Inhibitors and Their Use in Precision Pediatric Oncology

The specific targeting of signal transduction by low-molecular-weight inhibitors or monoclonal antibodies represents a very promising personalized treatment strategy in pediatric oncology. In this study, we present the successful and clinically relevant use of commercially available phospho-protein...

Descripción completa

Detalles Bibliográficos
Autores principales:	Neradil, Jakub, Kyr, Michal, Polaskova, Kristyna, Kren, Leos, Macigova, Petra, Skoda, Jan, Sterba, Jaroslav, Veselska, Renata
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763615/ https://www.ncbi.nlm.nih.gov/pubmed/31616636 http://dx.doi.org/10.3389/fonc.2019.00930

Ejemplares similares

Effects of Sunitinib and Other Kinase Inhibitors on Cells Harboring a PDGFRB Mutation Associated with Infantile Myofibromatosis
por: Sramek, Martin, et al.
Publicado: (2018)

DHFR-mediated effects of methotrexate in medulloblastoma and osteosarcoma cells: The same outcome of treatment with different doses in sensitive cell lines
por: NERADIL, JAKUB, et al.
Publicado: (2015)

Individualization of Treatment Improves the Survival of Children With High-Risk Solid Tumors: Comparative Patient Series Analysis in a Real-Life Scenario
por: Kyr, Michal, et al.
Publicado: (2019)

Atypical nuclear localization of CD133 plasma membrane glycoprotein in rhabdomyosarcoma cell lines
por: NUNUKOVA, ALENA, et al.
Publicado: (2015)

Non-DHFR-mediated effects of methotrexate in osteosarcoma cell lines: epigenetic alterations and enhanced cell differentiation
por: Sramek, Martin, et al.
Publicado: (2016)

Assessment of Tumor Mutational Burden in Pediatric Tumors by Real-Life Whole-Exome Sequencing and In Silico Simulation of Targeted Gene Panels: How the Choice of Method Could Affect the Clinical Decision?
por: Noskova, Hana, et al.
Publicado: (2020)

Uniformity under in vitro conditions: Changes in the phenotype of cancer cell lines derived from different medulloblastoma subgroups
por: Chlapek, Petr, et al.
Publicado: (2017)

Novel Thiosemicarbazones Sensitize Pediatric Solid Tumor Cell-Types to Conventional Chemotherapeutics through Multiple Molecular Mechanisms
por: Paukovcekova, Silvia, et al.
Publicado: (2020)

The ATRA-induced differentiation of medulloblastoma cells is enhanced with LOX/COX inhibitors: an analysis of gene expression
por: Chlapek, Petr, et al.
Publicado: (2014)

Serial Xenotransplantation in NSG Mice Promotes a Hybrid Epithelial/Mesenchymal Gene Expression Signature and Stemness in Rhabdomyosarcoma Cells
por: Skoda, Jan, et al.
Publicado: (2020)

Comparative Analysis of Putative Prognostic and Predictive Markers in Neuroblastomas: High Expression of PBX1 Is Associated With a Poor Response to Induction Therapy
por: Veselska, Renata, et al.
Publicado: (2019)

The power of natural phenolic compounds: caffeic acid is able to enhance the retinoid-induced differentiation of tumor cells
por: Veselska, Renata, et al.
Publicado: (2014)

NANOG/NANOGP8 Localizes at the Centrosome and is Spatiotemporally Associated with Centriole Maturation
por: Mikulenkova, Erika, et al.
Publicado: (2020)

Repurposing Tyrosine Kinase Inhibitors to Overcome Multidrug Resistance in Cancer: A Focus on Transporters and Lysosomal Sequestration
por: Krchniakova, Maria, et al.
Publicado: (2020)

Iron-Chelation Treatment by Novel Thiosemicarbazone Targets Major Signaling Pathways in Neuroblastoma
por: Macsek, Peter, et al.
Publicado: (2021)

Case report: rapid and durable response to PDGFR targeted therapy in a child with refractory multiple infantile myofibromatosis and a heterozygous germline mutation of the PDGFRB gene
por: Mudry, Peter, et al.
Publicado: (2017)

Editorial: Precision/Personalized Pediatric Oncology and Immune Therapies: Rather Customize Than Randomize
por: Kýr, Michal, et al.
Publicado: (2020)

CD133 Expression and Identification of CD133/nestin Positive Cells in Rhabdomyosarcomas and Rhabdomyosarcoma Cell Lines
por: Sana, Jiri, et al.
Publicado: (2011)

Thiosemicarbazones Can Act Synergistically with Anthracyclines to Downregulate CHEK1 Expression and Induce DNA Damage in Cell Lines Derived from Pediatric Solid Tumors
por: Paukovcekova, Silvia, et al.
Publicado: (2022)

Thiosemicarbazones and selected tyrosine kinase inhibitors synergize in pediatric solid tumors: NDRG1 upregulation and impaired prosurvival signaling in neuroblastoma cells
por: Krchniakova, Maria, et al.
Publicado: (2022)

Nestin as a marker of cancer stem cells
por: Neradil, Jakub, et al.
Publicado: (2015)

Comprehensive Molecular Profiling for Relapsed/Refractory Pediatric Burkitt Lymphomas—Retrospective Analysis of Three Real-Life Clinical Cases—Addressing Issues on Randomization and Customization at the Bedside
por: Polaskova, Kristyna, et al.
Publicado: (2020)

Co-Expression of Cancer Stem Cell Markers Corresponds to a Pro-Tumorigenic Expression Profile in Pancreatic Adenocarcinoma
por: Skoda, Jan, et al.
Publicado: (2016)

Traffic lights for retinoids in oncology: molecular markers of retinoid resistance and sensitivity and their use in the management of cancer differentiation therapy
por: Dobrotkova, Viera, et al.
Publicado: (2018)

Future paradigms for precision oncology
por: Klement, Giannoula Lakka, et al.
Publicado: (2016)

New Target for Precision Medicine Treatment of Giant-Cell Tumor of Bone: Sunitinib Is Effective in the Treatment of Neoplastic Stromal Cells with Activated PDGFRβ Signaling
por: Mahdal, Michal, et al.
Publicado: (2021)

Enhanced Antiproliferative Effect of Combined Treatment with Calcitriol and All-Trans Retinoic Acid in Relation to Vitamin D Receptor and Retinoic Acid Receptor α Expression in Osteosarcoma Cell Lines
por: Paukovcekova, Silvia, et al.
Publicado: (2020)

The Expression of c-Myb Correlates with the Levels of Rhabdomyosarcoma-specific Marker Myogenin
por: Kaspar, Petr, et al.
Publicado: (2015)

Why Differentiation Therapy Sometimes Fails: Molecular Mechanisms of Resistance to Retinoids
por: Chlapek, Petr, et al.
Publicado: (2018)

Nestin expression in the cell lines derived from glioblastoma multiforme
por: Veselska, Renata, et al.
Publicado: (2006)

N-of-1 Trials in Pediatric Oncology: From a Population-Based Approach to Personalized Medicine—A Review
por: Kyr, Michal, et al.
Publicado: (2021)

Enhancement of ATRA-induced differentiation of neuroblastoma cells with LOX/COX inhibitors: an expression profiling study
por: Chlapek, Petr, et al.
Publicado: (2010)

Improved osteosarcoma survival with addition of mifamurtide to conventional chemotherapy – Observational prospective single institution analysis
por: Múdry, Peter, et al.
Publicado: (2021)

Prediction of neuroblastoma cell response to treatment with natural or synthetic retinoids using selected protein biomarkers
por: Dobrotkova, Viera, et al.
Publicado: (2019)

Minimal Residual Disease–Guided Intermittent Dosing in Patients With Cancer: Successful Treatment of Chemoresistant Anaplastic Large Cell Lymphoma Using Intermittent Lorlatinib Dosing
por: Pokorna, Petra, et al.
Publicado: (2022)

Nestin expression in osteosarcomas and derivation of nestin/CD133 positive osteosarcoma cell lines
por: Veselska, Renata, et al.
Publicado: (2008)

Modeling effect of the septic condition and trauma on C-reactive protein levels in children with sepsis: a retrospective study
por: Kyr, Michal, et al.
Publicado: (2007)

Tris(2-carbamoylguanidinium) hydrogen fluorophosphonate fluorophosphonate monohydrate
por: Fábry, Jan, et al.
Publicado: (2011)

Phospho-Mimetic Mutation at Ser602 Inactivates Human TRPA1 Channel
por: Barvikova, Kristyna, et al.
Publicado: (2020)

Acetonyltriphenylphosphonium nitrate
por: Diop, Tidiane, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_aghhh87mj1msi2var6cme4phnl