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Nonsecretor Histo–blood Group Antigen Phenotype Is Associated With Reduced Risk of Clinical Rotavirus Vaccine Failure in Malawian Infants

BACKGROUND: Histo–blood group antigen (HBGA) Lewis/secretor phenotypes predict genotype-specific susceptibility to rotavirus gastroenteritis (RVGE). We tested the hypothesis that nonsecretor/Lewis-negative phenotype leads to reduced vaccine take and lower clinical protection following vaccination wi...

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Detalles Bibliográficos
Autores principales: Pollock, Louisa, Bennett, Aisleen, Jere, Khuzwayo C, Dube, Queen, Mandolo, Jonathan, Bar-Zeev, Naor, Heyderman, Robert S, Cunliffe, Nigel A, Iturriza-Gomara, Miren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763638/
https://www.ncbi.nlm.nih.gov/pubmed/30561537
http://dx.doi.org/10.1093/cid/ciy1067