Oncofetal HMGA2 attenuates genotoxic damage induced by topoisomerase II target compounds through the regulation of local DNA topology

Rapidly dividing cells maintain chromatin supercoiling homeostasis via two specialized classes of enzymes, DNA topoisomerase type 1 and 2 (TOP1/2). Several important anticancer drugs perturb this homeostasis by targeting TOP1/2, thereby generating genotoxic DNA damage. Our recent studies indicated t...

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Detalles Bibliográficos
Autores principales: Ahmed, Syed Moiz, Dröge, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763970/
https://www.ncbi.nlm.nih.gov/pubmed/31271486
http://dx.doi.org/10.1002/1878-0261.12541

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763970/
https://www.ncbi.nlm.nih.gov/pubmed/31271486
http://dx.doi.org/10.1002/1878-0261.12541

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