The Stapled Peptide PM2 Stabilizes p53 Levels and Radiosensitizes Wild-Type p53 Cancer Cells

The tumor suppressor p53 is a key mediator of cellular stress and DNA damage response cascades and is activated after exposure to ionizing radiation. Amplifying wild-type p53 expression by targeting negative regulators such as MDM2 in combination with external beam radiotherapy (EBRT) may result in...

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Detalles Bibliográficos
Autores principales: Mortensen, Anja Charlotte Lundgren, Spiegelberg, Diana, Brown, Christopher John, Lane, David Philip, Nestor, Marika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764291/
https://www.ncbi.nlm.nih.gov/pubmed/31616635
http://dx.doi.org/10.3389/fonc.2019.00923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764291/
https://www.ncbi.nlm.nih.gov/pubmed/31616635
http://dx.doi.org/10.3389/fonc.2019.00923

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