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The Trials and Tribulations of Structure Assisted Design of K(Ca) Channel Activators
Calcium-activated K(+) channels constitute attractive targets for the treatment of neurological and cardiovascular diseases. To explain why certain 2-aminobenzothiazole/oxazole-type K(Ca) activators (SKAs) are K(Ca)3.1 selective we previously generated homology models of the C-terminal calmodulin-bi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764326/ https://www.ncbi.nlm.nih.gov/pubmed/31616290 http://dx.doi.org/10.3389/fphar.2019.00972 |