Blocking the FKBP12 induced dendrimeric burst in aberrant aggregation of α-synuclein by using the ElteN378 synthetic inhibitor

α-Synuclein (α-syn), a disordered cytoplasmatic protein, plays a fundamental role in the pathogenesis of Parkinson’s disease (PD). Here, we have shown, using photophysical measurements, that addition of FKBP12 to α-syn solutions, dramatically accelerates protein aggregation, leading to an explosion...

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Detalles Bibliográficos
Autores principales: Caminati, Gabriella, Martina, Maria Raffaella, Menichetti, Stefano, Procacci, Piero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764402/
https://www.ncbi.nlm.nih.gov/pubmed/31547734
http://dx.doi.org/10.1080/14756366.2019.1667342

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764402/
https://www.ncbi.nlm.nih.gov/pubmed/31547734
http://dx.doi.org/10.1080/14756366.2019.1667342

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