Exploring mTOR inhibition as treatment for mitochondrial disease

Leigh syndrome and MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke‐like episodes) are two of the most frequent pediatric mitochondrial diseases. Both cause severe morbidity and neither have effective treatment. Inhibiting the mammalian target of rapamycin (mTOR) pathway has been...

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Detalles Bibliográficos
Autores principales: Sage‐Schwaede, Abigail, Engelstad, Kristin, Salazar, Rachel, Curcio, Angela, Khandji, Alexander, Garvin Jr, James H., De Vivo, Darryl C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764630/
https://www.ncbi.nlm.nih.gov/pubmed/31386302
http://dx.doi.org/10.1002/acn3.50846

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764630/
https://www.ncbi.nlm.nih.gov/pubmed/31386302
http://dx.doi.org/10.1002/acn3.50846

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