Comparative phenotypic profiling of the JAK2 inhibitors ruxolitinib, fedratinib, momelotinib, and pacritinib reveals distinct mechanistic signatures

Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling is critical to multiple cellular processes, including survival, differentiation, and proliferation. JAK-STAT signaling dysregulation has been noted in inflammatory disorders, and aberrant JAK2 pathway activation has...

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Detalles Bibliográficos
Autores principales: Singer, Jack W., Al-Fayoumi, Suliman, Taylor, Jason, Velichko, Sharlene, O’Mahony, Alison
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764664/
https://www.ncbi.nlm.nih.gov/pubmed/31560729
http://dx.doi.org/10.1371/journal.pone.0222944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764664/
https://www.ncbi.nlm.nih.gov/pubmed/31560729
http://dx.doi.org/10.1371/journal.pone.0222944

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