The Peptide-Directed Lysosomal Degradation of CDK5 Exerts Therapeutic Effects against Stroke

The aberrant activation of CDK5 has been implicated in neuronal death in stroke. The goal of this study is to determine whether knocking down CDK5 by a peptide-directed lysosomal degradation approach is therapeutically effective against stroke. We synthesized a membrane-permeable peptide that specif...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Ya-Fan, Wang, Jing, Deng, Man-Fei, Chi, Bin, Wei, Na, Chen, Jian-Guo, Liu, Dan, Yin, Xiaoping, Lu, Youming, Zhu, Ling-Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JKL International LLC 2019
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764726/
https://www.ncbi.nlm.nih.gov/pubmed/31595208
http://dx.doi.org/10.14336/AD.2018.1225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764726/
https://www.ncbi.nlm.nih.gov/pubmed/31595208
http://dx.doi.org/10.14336/AD.2018.1225

Ejemplares similares