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The Peptide-Directed Lysosomal Degradation of CDK5 Exerts Therapeutic Effects against Stroke
The aberrant activation of CDK5 has been implicated in neuronal death in stroke. The goal of this study is to determine whether knocking down CDK5 by a peptide-directed lysosomal degradation approach is therapeutically effective against stroke. We synthesized a membrane-permeable peptide that specif...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
JKL International LLC
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764726/ https://www.ncbi.nlm.nih.gov/pubmed/31595208 http://dx.doi.org/10.14336/AD.2018.1225 |