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Slow depressurization following intradiscal injection leads to injectate leakage in a large animal model

Needle injection has been indicated as the most practical method of delivering therapeutic agents to the intervertebral disc due to the disc's largely avascular nature. As the disc is characterized by both high stiffness and low permeability, injection requires substantial pressure, which may n...

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Detalles Bibliográficos
Autores principales: Varden, Lara J., Nguyen, Duc T., Michalek, Arthur J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764785/
https://www.ncbi.nlm.nih.gov/pubmed/31572978
http://dx.doi.org/10.1002/jsp2.1061