The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism

Hedgehog (HH) ligands, classical morphogens that pattern embryonic tissues in all animals, are covalently coupled to two lipids-- a palmitoyl group at the N-terminus and a cholesteroyl group at the C-terminus. While the palmitoyl group binds and inactivates Patched 1 (PTCH1), the main receptor for H...

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Detalles Bibliográficos
Autores principales: Rudolf, Amalie F., Kinnebrew, Maia, Kowatsch, Christiane, Ansell, T. Bertie, Omari, Kamel El, Bishop, Benjamin, Pardon, Els, Schwab, Rebekka A., Malinauskas, Tomas, Qian, Mingxing, Duman, Ramona, Covey, Douglas F., Steyaert, Jan, Wagner, Armin, Sansom, Mark S. P., Rohatgi, Rajat, Siebold, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764859/
https://www.ncbi.nlm.nih.gov/pubmed/31548691
http://dx.doi.org/10.1038/s41589-019-0370-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764859/
https://www.ncbi.nlm.nih.gov/pubmed/31548691
http://dx.doi.org/10.1038/s41589-019-0370-y

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