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mRNA structure determines modification by pseudouridine synthase 1

Pseudouridine (Ψ) is a post-transcriptional RNA modification that alters RNA-RNA and RNA-protein interactions that affect gene expression. mRNA pseudouridylation was recently discovered as a widespread and conserved phenomenon, but the mechanisms responsible for selective, regulated pseudouridylatio...

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Detalles Bibliográficos
Autores principales: Carlile, Thomas M., Martinez, Nicole M., Schaening, Cassandra, Su, Amanda, Bell, Tristan A., Zinshteyn, Boris, Gilbert, Wendy V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764900/
https://www.ncbi.nlm.nih.gov/pubmed/31477916
http://dx.doi.org/10.1038/s41589-019-0353-z