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Connective tissue fibroblasts from highly regenerative mammals are refractory to ROS-induced cellular senescence

A surveillance system in mammals constantly monitors cell activity to protect against aberrant proliferation in response to damage, injury and oncogenic stress. Here we isolate and culture connective tissue fibroblasts from highly regenerative mammals (Acomys and Oryctolagus) to determine how these...

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Detalles Bibliográficos
Autores principales: Saxena, Sandeep, Vekaria, Hemendra, Sullivan, Patrick G., Seifert, Ashley W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764955/
https://www.ncbi.nlm.nih.gov/pubmed/31562333
http://dx.doi.org/10.1038/s41467-019-12398-w