Urothelial organoids originating from Cd49f(high) mouse stem cells display Notch-dependent differentiation capacity

Understanding urothelial stem cell biology and differentiation has been limited by the lack of methods for their unlimited propagation. Here, we establish mouse urothelial organoids that can be maintained uninterruptedly for >1 year. Organoid growth is dependent on EGF and Wnt activators. High CD...

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Detalles Bibliográficos
Autores principales: Santos, Catarina P., Lapi, Eleonora, Martínez de Villarreal, Jaime, Álvaro-Espinosa, Laura, Fernández-Barral, Asunción, Barbáchano, Antonio, Domínguez, Orlando, Laughney, Ashley M., Megías, Diego, Muñoz, Alberto, Real, Francisco X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764959/
https://www.ncbi.nlm.nih.gov/pubmed/31562298
http://dx.doi.org/10.1038/s41467-019-12307-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764959/
https://www.ncbi.nlm.nih.gov/pubmed/31562298
http://dx.doi.org/10.1038/s41467-019-12307-1

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