PFKFB3 inhibition reprograms malignant pleural mesothelioma to nutrient stress-induced macropinocytosis and ER stress as independent binary adaptive responses

The metabolic signatures of cancer cells are often associated with elevated glycolysis. Pharmacological (PFK158 treatment) and genetic inhibition of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), a critical control point in the glycolytic pathway, decreases glucose uptake, ATP produ...

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Detalles Bibliográficos
Autores principales: Sarkar Bhattacharya, Sayantani, Thirusangu, Prabhu, Jin, Ling, Roy, Debarshi, Jung, Deokbeom, Xiao, Yinan, Staub, Julie, Roy, Bhaskar, Molina, Julian R., Shridhar, Viji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764980/
https://www.ncbi.nlm.nih.gov/pubmed/31562297
http://dx.doi.org/10.1038/s41419-019-1916-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764980/
https://www.ncbi.nlm.nih.gov/pubmed/31562297
http://dx.doi.org/10.1038/s41419-019-1916-3

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