Cargando…

Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy

We studied the effects of intestinal inflammation on pentylenetetrazole (PTZ)-induced seizures in mice and the effects thereon of some antiepileptic and anti-inflammatory treatments to establish if a link may exist. The agents tested were: alpha-lactoalbumin (ALAC), a whey protein rich in tryptophan...

Descripción completa

Detalles Bibliográficos
Autores principales:	De Caro, Carmen, Leo, Antonio, Nesci, Valentina, Ghelardini, Carla, di Cesare Mannelli, Lorenzo, Striano, Pasquale, Avagliano, Carmen, Calignano, Antonio, Mainardi, Paolo, Constanti, Andrew, Citraro, Rita, De Sarro, Giovambattista, Russo, Emilio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764994/ https://www.ncbi.nlm.nih.gov/pubmed/31562378 http://dx.doi.org/10.1038/s41598-019-50542-0

Ejemplares similares

Pain Modulation in WAG/Rij Epileptic Rats (A Genetic Model of Absence Epilepsy): Effects of Biological and Pharmacological Histone Deacetylase Inhibitors
por: De Caro, Carmen, et al.
Publicado: (2020)

Seizure susceptibility to various convulsant stimuli in the BTBR mouse model of autism spectrum disorders
por: Tallarico, Martina, et al.
Publicado: (2023)

Phaseolus vulgaris L. Extract: Alpha-Amylase Inhibition against Metabolic Syndrome in Mice
por: Micheli, Laura, et al.
Publicado: (2019)

Analgesic and Anti-Inflammatory Effects of Perampanel in Acute and Chronic Pain Models in Mice: Interaction With the Cannabinergic System
por: De Caro, Carmen, et al.
Publicado: (2021)

Peroxisome proliferator-activated receptor alpha plays a crucial role in behavioral repetition and cognitive flexibility in mice
por: D'Agostino, Giuseppe, et al.
Publicado: (2015)

mGlu3 Metabotropic Glutamate Receptors as a Target for the Treatment of Absence Epilepsy: Preclinical and Human Genetics Data
por: Celli, Roberta, et al.
Publicado: (2023)

Metabolic and Cognitive Effects of Ranolazine in Type 2 Diabetes Mellitus: Data from an in vivo Model
por: Cassano, Velia, et al.
Publicado: (2020)

Phaseolus vulgaris extract ameliorates high-fat diet-induced colonic barrier dysfunction and inflammation in mice by regulating peroxisome proliferator-activated receptor expression and butyrate levels
por: Avagliano, Carmen, et al.
Publicado: (2022)

Pharmacokinetic Interactions of Clinical Interest Between Direct Oral Anticoagulants and Antiepileptic Drugs
por: Galgani, Alessandro, et al.
Publicado: (2018)

Effects of a probiotic suspension Symprove™ on a rat early-stage Parkinson’s disease model
por: Sancandi, Marco, et al.
Publicado: (2023)

Corrigendum: Pharmacokinetic Interactions of Clinical Interest Between Direct Oral Anticoagulants and Antiepileptic Drugs
por: Galgani, Alessandro, et al.
Publicado: (2020)

Antiepileptic Effect of Neuroaid(®) on Strychnine-Induced Convulsions in Mice
por: Salim Mahmood, Ahmed, et al.
Publicado: (2022)

The Beneficial Effects of Ultramicronized Palmitoylethanolamide in the Management of Neuropathic Pain and Associated Mood Disorders Induced by Paclitaxel in Mice
por: Cristiano, Claudia, et al.
Publicado: (2022)

Ranolazine Attenuates Brain Inflammation in a Rat Model of Type 2 Diabetes
por: Cassano, Velia, et al.
Publicado: (2022)

The Protective Role of Butyrate against Obesity and Obesity-Related Diseases
por: Coppola, Serena, et al.
Publicado: (2021)

Characterization of New TRPM8 Modulators in Pain Perception
por: De Caro, Carmen, et al.
Publicado: (2019)

The Anticonvulsant Activity of a Flavonoid-Rich Extract from Orange Juice Involves both NMDA and GABA-Benzodiazepine Receptor Complexes
por: Citraro, Rita, et al.
Publicado: (2016)

Comparative effectiveness of antiepileptic drugs in juvenile myoclonic epilepsy
por: Silvennoinen, Katri, et al.
Publicado: (2019)

The microbiota‐gut‐brain axis and epilepsy from a multidisciplinary perspective: Clinical evidence and technological solutions for improvement of in vitro preclinical models
por: Fusco, Federica, et al.
Publicado: (2022)

Audiogenic epileptic DBA/2 mice strain as a model of genetic reflex seizures and SUDEP
por: Bosco, Francesca, et al.
Publicado: (2023)

Colchicine in Managing Skin Conditions: A Systematic Review
por: Dastoli, Stefano, et al.
Publicado: (2022)

Antiseizure Medications in Alzheimer’s Disease from Preclinical to Clinical Evidence
por: Bosco, Francesca, et al.
Publicado: (2023)

Antiepileptic Drug Treatment in Children with Epilepsy
por: Rosati, Anna, et al.
Publicado: (2015)

Brivaracetam: review of its pharmacology and potential use as adjunctive therapy in patients with partial onset seizures
por: Mumoli, Laura, et al.
Publicado: (2015)

Profile of brivaracetam and its potential in the treatment of epilepsy
por: Ferlazzo, Edoardo, et al.
Publicado: (2015)

The Antiepileptic Drug Levetiracetam Suppresses Non-Convulsive Seizure Activity and Reduces Ischemic Brain Damage in Rats Subjected to Permanent Middle Cerebral Artery Occlusion
por: Cuomo, Ornella, et al.
Publicado: (2013)

The effect of complicated febrile convulsion on hippocampal function and its antiepileptic treatment significance
por: Li, Bin, et al.
Publicado: (2021)

Use of Antiepileptic Drugs for Hyperkinetic Movement Disorders
por: Siniscalchi, A, et al.
Publicado: (2010)

Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy: Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism
por: Di Cesare Mannelli, L., et al.
Publicado: (2013)

An In Vivo Electroencephalographic Analysis of the Effect of Riluzole against Limbic and Absence Seizure and Comparison with Glutamate Antagonists
por: Citraro, Rita, et al.
Publicado: (2023)

Pediatric Drug Safety Surveillance: A 10-Year Analysis of Adverse Drug Reaction Reporting Data in Calabria, Southern Italy
por: Leporini, Christian, et al.
Publicado: (2022)

Epilepsy and Convulsive Disorders in Children
Publicado: (1949)

Convulsions in Childhood and Their Relation to Epilepsy
por: Shanks, Robert A.
Publicado: (1951)

Antiepileptic Drug Withdrawal in Dogs with Epilepsy
por: Gesell, Felix Kaspar, et al.
Publicado: (2015)

Discontinuation of antiepileptic drugs in adults with epilepsy
por: Laue-Gizzi, Hanka
Publicado: (2021)

Association of Anemia With Epilepsy and Antiepileptic Drugs
por: Padda, Jaskamal, et al.
Publicado: (2021)

Genetic Background of Epilepsy and Antiepileptic Treatments
por: Borowicz-Reutt, Kinga, et al.
Publicado: (2023)

Prevalence and mortality of epilepsies with convulsive and non-convulsive seizures in Kilifi, Kenya
por: Kariuki, Symon M, et al.
Publicado: (2021)

Drug-Induced Sexual Dysfunction in Individuals with Epilepsy: Beyond Antiepileptic Compounds
por: Calabrò, Rocco Salvatore, et al.
Publicado: (2022)

An Open Retrospective Study of a Standardized Cannabidiol Based-Oil in Treatment-Resistant Epilepsy
por: Marchese, Francesca, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_von1ta34ceeh9tib348b1mtkf9