Repair of base damage within break-induced replication intermediates promotes kataegis associated with chromosome rearrangements

Break induced replication (BIR) is a double strand break repair pathway that can promote genetic instabilities similar to those observed in cancer. Instead of a replication fork, BIR is driven by a migration bubble where asynchronous synthesis between leading and lagging strands leads to accumulatio...

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Detalles Bibliográficos
Autores principales: Elango, Rajula, Osia, Beth, Harcy, Victoria, Malc, Ewa, Mieczkowski, Piotr A, Roberts, Steven A, Malkova, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765108/
https://www.ncbi.nlm.nih.gov/pubmed/31392335
http://dx.doi.org/10.1093/nar/gkz651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765108/
https://www.ncbi.nlm.nih.gov/pubmed/31392335
http://dx.doi.org/10.1093/nar/gkz651

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