PPARβ/δ recruits NCOR and regulates transcription reinitiation of ANGPTL4

In the absence of ligands, the nuclear receptor PPARβ/δ recruits the NCOR and SMRT corepressors, which form complexes with HDAC3, to canonical target genes. Agonistic ligands cause dissociation of corepressors and enable enhanced transcription. Vice versa, synthetic inverse agonists augment corepres...

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Detalles Bibliográficos
Autores principales: Legrand, Nathalie, Bretscher, Clemens L, Zielke, Svenja, Wilke, Bernhard, Daude, Michael, Fritz, Barbara, Diederich, Wibke E, Adhikary, Till
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765110/
https://www.ncbi.nlm.nih.gov/pubmed/31428774
http://dx.doi.org/10.1093/nar/gkz685

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765110/
https://www.ncbi.nlm.nih.gov/pubmed/31428774
http://dx.doi.org/10.1093/nar/gkz685

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