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Polymerase synthesis of four-base DNA from two stable dimeric nucleotides

We document the preparation and properties of dimerized pentaphosphate-bridged deoxynucleotides (dicaptides) that contain reactive components of two different nucleotides simultaneously. Importantly, dicaptides are found to be considerably more stable to hydrolysis than standard dNTPs. Steady-state...

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Detalles Bibliográficos
Autores principales:	Mohsen, Michael G, Ji, Debin, Kool, Eric T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765132/ https://www.ncbi.nlm.nih.gov/pubmed/31504784 http://dx.doi.org/10.1093/nar/gkz741

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