Cargando…

Structure and DNA damage-dependent derepression mechanism for the XRE family member DG-DdrO

DdrO is an XRE family transcription repressor that, in coordination with the metalloprotease PprI, is critical in the DNA damage response of Deinococcus species. Here, we report the crystal structure of Deinococcus geothermalis DdrO. Biochemical and structural studies revealed the conserved recogniz...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Huizhi, Wang, Liangyan, Li, Shengjie, Pan, Chaoming, Cheng, Kaiying, Luo, Yuxia, Xu, Hong, Tian, Bing, Zhao, Ye, Hua, Yuejin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765133/ https://www.ncbi.nlm.nih.gov/pubmed/31410466 http://dx.doi.org/10.1093/nar/gkz720

Ejemplares similares

Crystal structure of the transcriptional repressor DdrO: insight into the metalloprotease/repressor-controlled radiation response in Deinococcus
por: de Groot, Arjan, et al.
Publicado: (2019)

Conservation and diversity of the IrrE/DdrO‐controlled radiation response in radiation‐resistant Deinococcus bacteria
por: Blanchard, Laurence, et al.
Publicado: (2017)

Structural basis for DNA 5´-end resection by RecJ
por: Cheng, Kaiying, et al.
Publicado: (2016)

Transcriptional activation of ompA in Neisseria gonorrhoeae mediated by the XRE family member protein NceR
por: Holley, Concerta L., et al.
Publicado: (2023)

Structural and functional characterization of DdrC, a novel DNA damage-induced nucleoid associated protein involved in DNA compaction
por: Banneville, Anne-Sophie, et al.
Publicado: (2022)

Participation of RecJ in the base excision repair pathway of Deinococcus radiodurans
por: Cheng, Kaiying, et al.
Publicado: (2020)

Structural basis for 2′-deoxyguanosine recognition by the 2′-dG-II class of riboswitches
por: Matyjasik, Michal M, et al.
Publicado: (2019)

The structure of DdrB from Deinococcus: a new fold for single-stranded DNA binding proteins
por: Sugiman-Marangos, Seiji, et al.
Publicado: (2010)

The XRE Family Transcriptional Regulator SrtR in Streptococcus suis Is Involved in Oxidant Tolerance and Virulence
por: Hu, Yuli, et al.
Publicado: (2019)

Influence of flanking sequence context on the conformational flexibility of aminofluorene-modified dG adduct in dA mismatch DNA duplexes
por: Jain, Nidhi, et al.
Publicado: (2009)

Following an environmental carcinogen N(2)-dG adduct through replication: elucidating blockage and bypass in a high-fidelity DNA polymerase
por: Xu, Pingna, et al.
Publicado: (2007)

Crystal structure of the DdrB/ssDNA complex from Deinococcus radiodurans reveals a DNA binding surface involving higher-order oligomeric states
por: Sugiman-Marangos, Seiji N., et al.
Publicado: (2013)

DRJAMM Is Involved in the Oxidative Resistance in Deinococcus radiodurans
por: Cai, Jianling, et al.
Publicado: (2022)

DNA Damage Response (DDR) and DNA Repair
por: Vernì, Fiammetta
Publicado: (2022)

DNA translocation mechanism of an XPD family helicase
por: Cheng, Kaiying, et al.
Publicado: (2018)

MsrR is a thiol-based oxidation-sensing regulator of the XRE family that modulates C. glutamicum oxidative stress resistance
por: Si, Meiru, et al.
Publicado: (2020)

PprI: The Key Protein in Response to DNA Damage in Deinococcus
por: Lu, Huizhi, et al.
Publicado: (2021)

A Novel C-Terminal Domain of RecJ is Critical for Interaction with HerA in Deinococcus radiodurans
por: Cheng, Kaiying, et al.
Publicado: (2015)

N(4)-Cytosine DNA Methylation Is Involved in the Maintenance of Genomic Stability in Deinococcus radiodurans
por: Li, Shengjie, et al.
Publicado: (2019)

ErpC, a member of the complement regulator-acquiring family of surface proteins from Borrelia burgdorferi, possesses an architecture previously unseen in this protein family
por: Caesar, Joseph J. E., et al.
Publicado: (2013)

Yeast Ssd1 is a non-enzymatic member of the RNase II family with an alternative RNA recognition site
por: Bayne, Rosemary A, et al.
Publicado: (2021)

Two novel XRE-like transcriptional regulators control phenotypic heterogeneity in Photorhabdus luminescens cell populations
por: Eckstein, Simone, et al.
Publicado: (2021)

Transcription Inhibitors with XRE DNA-Binding and Cupin Signal-Sensing Domains Drive Metabolic Diversification in Pseudomonas
por: Trouillon, Julian, et al.
Publicado: (2021)

XRE Transcription Factors Conserved in Caulobacter and φCbK Modulate Adhesin Development and Phage Production
por: McLaughlin, Maeve, et al.
Publicado: (2023)

XRE transcription factors conserved in Caulobacter and φCbK modulate adhesin development and phage production
por: McLaughlin, Maeve, et al.
Publicado: (2023)

DG' Presentation
por: Heuer, Rolf
Publicado: (2015)

DG Euronews
Publicado: (1997)

Presentation of the DG
por: CERN. Geneva
Publicado: (2010)

Speach of the DG
por: Llewellyn Smith, Christopher Hubert
Publicado: (1997)

DG's Presentation
por: Gianotti, Fabiola
Publicado: (2016)

Why Human Papillomaviruses Activate the DNA Damage Response (DDR) and How Cellular and Viral Replication Persists in the Presence of DDR Signaling
por: Bristol, Molly L., et al.
Publicado: (2017)

DDR-mediated crosstalk between DNA-damaged cells and their microenvironment
por: Malaquin, Nicolas, et al.
Publicado: (2015)

DG's staff talk
por: CERN. Geneva. Experimental Physics (EP) division
Publicado: (2001)

DG's Staff meeting
por: CERN. Geneva. Experimental Physics (EP) division
Publicado: (2000)

Introduction to CERN by the DG
por: Heuer, Rolf
Publicado: (2014)

DG's talk to Staff
por: CERN. Geneva
Publicado: (2011)

DG's Staff Meeting
por: Rubbia, Carlo
Publicado: (1990)

DG Staff Meeting
por: Rubbia, Carlo
Publicado: (1989)

DG-Computing policy
por: Krige, A
Publicado: (1986)

Message from the DG
por: Aymar, R
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_ab0f67oa2vmug56kk6dvurjkha