Structural and functional insight into the Mycobacterium tuberculosis protein PrpR reveals a novel type of transcription factor

The pathogenicity of Mycobacterium tuberculosis depends upon its ability to catabolize host cholesterol. Upregulation of the methylcitrate cycle (MCC) is required to assimilate and detoxify propionyl-CoA, a cholesterol degradation product. The transcription of key genes prpC and prpD in MCC is activ...

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Detalles Bibliográficos
Autores principales: Tang, Su, Hicks, Nathan D, Cheng, Yu-Shan, Silva, Andres, Fortune, Sarah M, Sacchettini, James C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765138/
https://www.ncbi.nlm.nih.gov/pubmed/31504787
http://dx.doi.org/10.1093/nar/gkz724

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765138/
https://www.ncbi.nlm.nih.gov/pubmed/31504787
http://dx.doi.org/10.1093/nar/gkz724

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