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Structural and functional insight into the Mycobacterium tuberculosis protein PrpR reveals a novel type of transcription factor
The pathogenicity of Mycobacterium tuberculosis depends upon its ability to catabolize host cholesterol. Upregulation of the methylcitrate cycle (MCC) is required to assimilate and detoxify propionyl-CoA, a cholesterol degradation product. The transcription of key genes prpC and prpD in MCC is activ...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765138/ https://www.ncbi.nlm.nih.gov/pubmed/31504787 http://dx.doi.org/10.1093/nar/gkz724 |