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Programmed genome rearrangements in Oxytricha produce transcriptionally active extrachromosomal circular DNA
Extrachromosomal circular DNA (eccDNA) is both a driver of eukaryotic genome instability and a product of programmed genome rearrangements, but its extent had not been surveyed in Oxytricha, a ciliate with elaborate DNA elimination and translocation during development. Here, we captured rearrangemen...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765146/ https://www.ncbi.nlm.nih.gov/pubmed/31504770 http://dx.doi.org/10.1093/nar/gkz725 |