Programmed genome rearrangements in Oxytricha produce transcriptionally active extrachromosomal circular DNA

Extrachromosomal circular DNA (eccDNA) is both a driver of eukaryotic genome instability and a product of programmed genome rearrangements, but its extent had not been surveyed in Oxytricha, a ciliate with elaborate DNA elimination and translocation during development. Here, we captured rearrangemen...

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Detalles Bibliográficos
Autores principales: Yerlici, V Talya, Lu, Michael W, Hoge, Carla R, Miller, Richard V, Neme, Rafik, Khurana, Jaspreet S, Bracht, John R, Landweber, Laura F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765146/
https://www.ncbi.nlm.nih.gov/pubmed/31504770
http://dx.doi.org/10.1093/nar/gkz725

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