EWS–FLI1 modulated alternative splicing of ARID1A reveals novel oncogenic function through the BAF complex

Connections between epigenetic reprogramming and transcription or splicing create novel mechanistic networks that can be targeted with tailored therapies. Multiple subunits of the chromatin remodeling BAF complex, including ARID1A, play a role in oncogenesis, either as tumor suppressors or oncogenes...

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Detalles Bibliográficos
Autores principales: Selvanathan, Saravana P, Graham, Garrett T, Grego, Alexander R, Baker, Tabari M, Hogg, J Robert, Simpson, Mark, Batish, Mona, Crompton, Brian, Stegmaier, Kimberly, Tomazou, Eleni M, Kovar, Heinrich, Üren, Aykut, Toretsky, Jeffrey A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765149/
https://www.ncbi.nlm.nih.gov/pubmed/31392992
http://dx.doi.org/10.1093/nar/gkz699

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765149/
https://www.ncbi.nlm.nih.gov/pubmed/31392992
http://dx.doi.org/10.1093/nar/gkz699

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