A protein architecture guided screen for modification dependent restriction endonucleases

Modification dependent restriction endonucleases (MDREs) often have separate catalytic and modification dependent domains. We systematically looked for previously uncharacterized fusion proteins featuring a PUA or DUF3427 domain and HNH or PD-(D/E)XK catalytic domain. The enzymes were clustered by s...

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Detalles Bibliográficos
Autores principales: Lutz, Thomas, Flodman, Kiersten, Copelas, Alyssa, Czapinska, Honorata, Mabuchi, Megumu, Fomenkov, Alexey, He, Xinyi, Bochtler, Matthias, Xu, Shuang-yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765204/
https://www.ncbi.nlm.nih.gov/pubmed/31504772
http://dx.doi.org/10.1093/nar/gkz755

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765204/
https://www.ncbi.nlm.nih.gov/pubmed/31504772
http://dx.doi.org/10.1093/nar/gkz755

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