Ligand Conjugated Multimeric siRNAs Enable Enhanced Uptake and Multiplexed Gene Silencing

Small interfering RNAs (siRNAs) conjugated to N-acetylgalactosamine (GalNAc) ligands have been used to treat disease in patients. However, conjugates with other ligands deliver siRNA less efficiently, limiting the development of new targeted therapies. Most approaches to enhancing the potency of suc...

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Detalles Bibliográficos
Autores principales: Brown, Jonathan M., Dahlman, James E., Neuman, Kristin K., Prata, Carla A.H., Krampert, Monika C., Hadwiger, Philipp M., Vornlocher, Hans-Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2019
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765208/
https://www.ncbi.nlm.nih.gov/pubmed/31393218
http://dx.doi.org/10.1089/nat.2019.0782

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765208/
https://www.ncbi.nlm.nih.gov/pubmed/31393218
http://dx.doi.org/10.1089/nat.2019.0782

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