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Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications
Metabolic remodelling has emerged as critical for stem cell pluripotency; however, the underlying mechanisms have yet to be fully elucidated. Here, we found that the glycine cleavage system (GCS) is highly activated to promote stem cell pluripotency and during somatic cell reprogramming. Mechanistic...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Life Science Alliance LLC
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765226/ https://www.ncbi.nlm.nih.gov/pubmed/31562192 http://dx.doi.org/10.26508/lsa.201900413 |