Neurodevelopmental mutation of giant ankyrin-G disrupts a core mechanism for axon initial segment assembly

Giant ankyrin-G (gAnkG) coordinates assembly of axon initial segments (AISs), which are sites of action potential generation located in proximal axons of most vertebrate neurons. Here, we identify a mechanism required for normal neural development in humans that ensures ordered recruitment of gAnkG...

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Detalles Bibliográficos
Autores principales: Yang, Rui, Walder-Christensen, Kathryn K., Lalani, Samir, Yan, Haidun, García-Prieto, Irene Díez, Álvarez, Sara, Fernández-Jaén, Alberto, Speltz, Laura, Jiang, Yong-Hui, Bennett, Vann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765234/
https://www.ncbi.nlm.nih.gov/pubmed/31451636
http://dx.doi.org/10.1073/pnas.1909989116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765234/
https://www.ncbi.nlm.nih.gov/pubmed/31451636
http://dx.doi.org/10.1073/pnas.1909989116

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