An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity

TRiC/CCT assists the folding of ∼10% of cytosolic proteins through an ATP-driven conformational cycle and is essential in maintaining protein homeostasis. Here, we determined an ensemble of cryo-electron microscopy (cryo-EM) structures of yeast TRiC at various nucleotide concentrations, with 4 open-...

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Detalles Bibliográficos
Autores principales: Jin, Mingliang, Han, Wenyu, Liu, Caixuan, Zang, Yunxiang, Li, Jiawei, Wang, Fangfang, Wang, Yanxing, Cong, Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765261/
https://www.ncbi.nlm.nih.gov/pubmed/31492816
http://dx.doi.org/10.1073/pnas.1903976116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765261/
https://www.ncbi.nlm.nih.gov/pubmed/31492816
http://dx.doi.org/10.1073/pnas.1903976116

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