Joint profiling of DNA methylation and chromatin architecture in single cells

We report a method, Methyl-HiC, which captures the chromosome conformation and DNA methylome together in a cell. We use it to reveal coordinated DNA methylation status between distal genomic segments that are in spatial proximity in the nucleus and delineate heterogeneity of both the chromatin archi...

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Detalles Bibliográficos
Autores principales: Li, Guoqiang, Liu, Yaping, Zhang, Yanxiao, Kubo, Naoki, Yu, Miao, Fang, Rongxin, Kellis, Manolis, Ren, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765429/
https://www.ncbi.nlm.nih.gov/pubmed/31384045
http://dx.doi.org/10.1038/s41592-019-0502-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765429/
https://www.ncbi.nlm.nih.gov/pubmed/31384045
http://dx.doi.org/10.1038/s41592-019-0502-z

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