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Joint profiling of DNA methylation and chromatin architecture in single cells

We report a method, Methyl-HiC, which captures the chromosome conformation and DNA methylome together in a cell. We use it to reveal coordinated DNA methylation status between distal genomic segments that are in spatial proximity in the nucleus and delineate heterogeneity of both the chromatin archi...

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Detalles Bibliográficos
Autores principales:	Li, Guoqiang, Liu, Yaping, Zhang, Yanxiao, Kubo, Naoki, Yu, Miao, Fang, Rongxin, Kellis, Manolis, Ren, Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765429/ https://www.ncbi.nlm.nih.gov/pubmed/31384045 http://dx.doi.org/10.1038/s41592-019-0502-z

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