Application of Physiologically‐Based and Population Pharmacokinetic Modeling for Dose Finding and Confirmation During the Pediatric Development of Moxifloxacin

Moxifloxacin is a widely used fluoroquinolone for the treatment of complicated intra‐abdominal infections. We applied physiologically‐based pharmacokinetic (PBPK) and population pharmacokinetic (popPK) modeling to support dose selection in pediatric patients. We scaled an existing adult PBPK model t...

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Detalles Bibliográficos
Autores principales: Willmann, Stefan, Frei, Matthias, Sutter, Gabriele, Coboeken, Katrin, Wendl, Thomas, Eissing, Thomas, Lippert, Jörg, Stass, Heino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765696/
https://www.ncbi.nlm.nih.gov/pubmed/31310051
http://dx.doi.org/10.1002/psp4.12446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765696/
https://www.ncbi.nlm.nih.gov/pubmed/31310051
http://dx.doi.org/10.1002/psp4.12446

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