Quantitative Systems Pharmacology Model of a Masked, Tumor‐Activated Antibody

PROBODY therapeutics (Pb‐Tx) are protease‐activatable prodrugs of monoclonal antibodies (mAbs) designed to target tumors where protease activity is elevated while avoiding normal tissue. They are composed of a parental mAb, a mask that inhibits antibody binding to target, and a protease‐cleavable su...

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Detalles Bibliográficos
Autores principales: Stroh, Mark, Sagert, Jason, Burke, John M., Apgar, Joshua F., Lin, Lin, Millard, Bjorn L., Michael Kavanaugh, W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765697/
https://www.ncbi.nlm.nih.gov/pubmed/31250966
http://dx.doi.org/10.1002/psp4.12448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765697/
https://www.ncbi.nlm.nih.gov/pubmed/31250966
http://dx.doi.org/10.1002/psp4.12448

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