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Quantitative Systems Pharmacology Model of a Masked, Tumor‐Activated Antibody

PROBODY therapeutics (Pb‐Tx) are protease‐activatable prodrugs of monoclonal antibodies (mAbs) designed to target tumors where protease activity is elevated while avoiding normal tissue. They are composed of a parental mAb, a mask that inhibits antibody binding to target, and a protease‐cleavable su...

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Detalles Bibliográficos
Autores principales:	Stroh, Mark, Sagert, Jason, Burke, John M., Apgar, Joshua F., Lin, Lin, Millard, Bjorn L., Michael Kavanaugh, W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765697/ https://www.ncbi.nlm.nih.gov/pubmed/31250966 http://dx.doi.org/10.1002/psp4.12448

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