Physiologically‐Based Pharmacokinetic Modeling of Atorvastatin Incorporating Delayed Gastric Emptying and Acid‐to‐Lactone Conversion

The drug–drug interaction profile of atorvastatin confirms that disposition is determined by cytochrome P450 (CYP) 3A4 and organic anion transporting polypeptides (OATPs). Drugs that affect gastric emptying, including dulaglutide, also affect atorvastatin pharmacokinetics (PK). Atorvastatin is a car...

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Detalles Bibliográficos
Autores principales: Morse, Bridget L., Alberts, Jeffrey J., Posada, Maria M., Rehmel, Jessica, Kolur, Anil, Tham, Lai San, Loghin, Corina, Hillgren, Kathleen M., Hall, Stephen D., Dickinson, Gemma L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765700/
https://www.ncbi.nlm.nih.gov/pubmed/31250974
http://dx.doi.org/10.1002/psp4.12447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765700/
https://www.ncbi.nlm.nih.gov/pubmed/31250974
http://dx.doi.org/10.1002/psp4.12447

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