CRISPR/Cas9 Knockout of Bak Mediates Bax Translocation to Mitochondria in response to TNFα/CHX-induced Apoptosis

TNFα/CHX-induced apoptosis is dependent on caspase-8 activation and regulated by Bcl-2. However, the specific participants and precise mechanisms underlying this apoptotic pathway are poorly understood. The proapoptotic proteins Bak and Bax—members of the Bcl-2 family—are essential for the functioni...

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Detalles Bibliográficos
Autores principales: Zhang, Jingtian, Niu, Han, Zhao, Zhizhuang Joe, Fu, Xueqi, Wang, Yuxiang, Zhang, Xu, Zhang, Fuqiang, Zeng, Linlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766168/
https://www.ncbi.nlm.nih.gov/pubmed/31637258
http://dx.doi.org/10.1155/2019/9071297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766168/
https://www.ncbi.nlm.nih.gov/pubmed/31637258
http://dx.doi.org/10.1155/2019/9071297

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