Development of a Fragment-Based Screening Assay for the Focal Adhesion Targeting Domain Using SPR and NMR

The Focal Adhesion Targeting (FAT) domain of Focal Adhesion Kinase (FAK) is a promising drug target since FAK is overexpressed in many malignancies and promotes cancer cell metastasis. The FAT domain serves as a scaffolding protein, and its interaction with the protein paxillin localizes FAK to foca...

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Detalles Bibliográficos
Autores principales: Alvarado, Carlos, Stahl, Erik, Koessel, Karissa, Rivera, Andrew, Cherry, Brian R., Pulavarti, Surya V.S.R.K., Szyperski, Thomas, Cance, William, Marlowe, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766811/
https://www.ncbi.nlm.nih.gov/pubmed/31540099
http://dx.doi.org/10.3390/molecules24183352

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766811/
https://www.ncbi.nlm.nih.gov/pubmed/31540099
http://dx.doi.org/10.3390/molecules24183352

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