A Secreted Phospholipase A(2) Induces Formation of Smooth Muscle Foam Cells Which Transdifferentiate to Macrophage-Like State

Vascular smooth muscle cells (VSMCs) loaded with lipid droplets (LDs) are markers of atherosclerosis. In this disease, inflammatory Group IIA-secreted phospholipase A(2)s (GIIA sPLA(2)s) are highly expressed in VSMCs, but their actions in these cells are unknown. Here, we investigated the ability of...

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Detalles Bibliográficos
Autores principales: Giannotti, Karina Cristina, Weinert, Sönke, Viana, Mariana Nascimento, Leiguez, Elbio, Araujo, Thaís L. S., Laurindo, Francisco R. M., Lomonte, Bruno, Braun-Dullaeus, Rüdiger, Teixeira, Catarina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766822/
https://www.ncbi.nlm.nih.gov/pubmed/31489892
http://dx.doi.org/10.3390/molecules24183244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766822/
https://www.ncbi.nlm.nih.gov/pubmed/31489892
http://dx.doi.org/10.3390/molecules24183244

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