Antiproliferative S-Trityl-l-Cysteine -Derived Compounds as SIRT2 Inhibitors: Repurposing and Solubility Enhancement

S-trityl-l-cysteine (STLC) is a well-recognized lead compound known for its anticancer activity owing to its potent inhibitory effect on human mitotic kinesin Eg5. STLC contains two free terminal amino and carboxyl groups that play pivotal roles in binding to the Eg5 pocket. On the other hand, such...

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Detalles Bibliográficos
Autores principales: Radwan, Mohamed O., Ciftci, Halil I., Ali, Taha F. S., Ellakwa, Doha E., Koga, Ryoko, Tateishi, Hiroshi, Nakata, Akiko, Ito, Akihiro, Yoshida, Minoru, Okamoto, Yoshinari, Fujita, Mikako, Otsuka, Masami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766826/
https://www.ncbi.nlm.nih.gov/pubmed/31510043
http://dx.doi.org/10.3390/molecules24183295

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766826/
https://www.ncbi.nlm.nih.gov/pubmed/31510043
http://dx.doi.org/10.3390/molecules24183295

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